Glipizide is an blood glucose lowering drug of sulphonyl urea class characterized by its poor aqueous solubility.The aim of present investigation was to improve the solubility of glipizide by using solid dispersion incorporated in situ gel.Various composition of glipizide dispersion were prepared by spray drying method using PVP 30,PVP-K90,�Ÿ-CD to enhanced solubility of drug. The formulations were evaluate for drug content, invitro dissolution study also characterized by IR .there was no any interaction between drug and carrier.Based on solubility and in-vitro drug release pattern 1:4 drug carrier ratio was selected as ideal dispersion for gel. The gel were characterized for rheological studies ,drug content estimation and invitro dissolution study,IR spectroscopy .all these properties were found to be ideal.Theinvitro release of glipizide solid dispersion incorporated gel is significantly improved. Stability study was performed according to ICH guidlines.
Loading....